Anti-inflammatory and antithrombotic properties of polar lipid extracts, rich in unsaturated fatty acids, from the Irish marine cyanobacterium Spirulina subsalsa

The characterization of cardio-protective lipid bioactives from cyanobacteria, such as Spirulina spp., has rarely been investigated. In this study, neutral lipids, glycolipids, and phospholipids Irish marine cyanobacterium subsalsa, were tested for anti-inflammatory antithrombotic activities in vitro human platelets. Glycolipids inhibited strongly platelet aggregation induced by platelet-activating factor (PAF) or thrombin, with IC50 (half maximal inhibitory concentration) values ranging ?60–110 µg polar lipids. characterisation the glycolipids revealed presence sulfoquinovosyl diacylglycerols (SQDG), monogalactosylodiglycerides (MGDG) glycosphingolipids (cerebrosides ceramides). Phospholipids contained mostly bioactive phosphatidylcholines (PC) phosphatidylethanolamines (PE) molecules as, diacyl-PC, diacyl-PE, alkyl-acyl PC, alkyl-acyl-PE, well considerable amounts phosphatidylglycerols (PG), phosphatidylinositols (PI), phosphatidylserines (PS), phosphatidic acids (PA). total properties makes subsalsa a candidate sustainable source health supplements cardiovascular benefits.